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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T62095 TRK-IN-19

TRK-IN-19 (Compound I-10 ) 是一种 TRK 的有效抑制剂,对 TRKATRKAG595R 的 IC50 值分别为 1.1 nM、5.3 nM。TRK-IN-19 对癌症疾病表现出潜在的研究价值。
T61443 Trk-IN-7

Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1].

化合物

TRK-IN-19
Cat.No: T62095
Synonym:
Target:
Trk-IN-7
Cat.No: T61443
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-00774 TrkA Protein, Human, Recombinant (aa 33-417, His)

TrkAI,TrkA I,Trk-A,T...

Human HEK293 Cells
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signaling pathways, resulting in diverse biological effects.

重组蛋白

TrkA Protein, Human, Recombinant (aa 33-417, His)
Cat.No: TMPK-00774
Species: Human
Expression System: HEK293 Cells
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